Endocrine Abstracts

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...

Background: Thyroid nodules are one of the most common clinical entities in Endocrinology practice. Fine needle aspiration (FNA) and the 2017 Bethesda System for Reporting Thyroid Cytopathology have been proved to be an effective tool to identify malignancy risk and guide surgical decision-making. However, thyroid nodules classified as Bethesda (BTH) III and IV remain a challenge, considering the varying risk of malignancy (ROM) found in different papers. The aim of this study...

Background: Thionamides are a class of drugs used to control thyrotoxicosis. A wide range of systemic adverse effects have been described, including agranulocytosis, rash, fever, arthralgia, hepatitis and even drug-induced lupus. Besides, there are some uncommon events related to their use, such as pleural effusion (only eight cases have been previously reported). We report a case of methimazole-induced eosinophilic pleural effusion.Case: Our patient is ...

Introduction: The aim of this study was to analyze the effects of Liraglutide in hepatic steatosis as well as clinical and biochemical data before and after 6 months.Methods: We have retrospectively analysed epidemiological, anthropometric and laboratory data of 83 type 2 diabetic patients treated with Liraglutide and followed at different endocrinology units across east Andalusia. We have evaluated nonalcoholic fatty liver disease using liver enzymes an...

Background: The increased risk for fractures in type 2 diabetes mellitus despite higher bone density is unexplained. Trabecular bone score (TBS) is a novel texture index related to bone microarchitecture and it is independent of bone mineral density (BMD). The aim of this study was to investigate the relationship between TBS, BMD and body composition in patients with New-Onset Diabetes after transplantation (NODAT).Methods: In a cross-sectional study, TB...

Background: The prolactin/vasoinhibin axis constitutes a novel endocrine axis in which the generation, secretion, and actions of the pituitary hormones prolactin and vasoinhibins are under control of the hypothalamus, the pituitary gland, and of regulators in the target tissue microenvironment. Vasoinhibins are generated in the pituitary gland and in multiple target tissues through proteolytic cleavage of prolactin; it is not known wether they are also produced in the circulat...

Obesity during gestation has been related to predisposition to endocrine and metabolic diseases in the offspring. Regarding reproductive effects, an increase in BMI in pregnant mothers is associated with precocious puberty in their offspring. This has been replicated in animal models of high fat diet (HFD) administration to mothers. Also, gestational obesity has been associated to higher susceptibility to developing breast cancer in the offspring. As both precocious puberty an...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...

Introduction: Postprandial glycemic control is complex as well as insufficient. Its impact on global metabolic control (HbA1c) is controversial with various works that support its influence in terms of glycemic variability and genesis of micro and/or macrovascular complications. Fiasp due to its special formulation allows a more effective control of postprandial glycemia being an interesting alternative to the rapid-acting insulin analogavailable.Objecti...

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...